Environmental Science & Technology 2016, 50 Chronic Exposure of Marine Medaka (Oryzias melastigma) to 4,5-Dichloro-2-n-octyl-4-isothiazolin-3-one (DCOIT) Reveals Its Mechanism of Action in Endocrine Disruption via the Hypothalamus-Pituitary-Gonadal-Liver (HPGL) Axis. Lianguo Chen, Weipeng Zhang, Rui Ye, Chenyan Hu, Qiangwei Wang, Frauke Seemann, Doris W.Endocrine Disruption throughout the Hypothalamus–Pituitary–Gonadal–Liver (HPGL) Axis in Marine Medaka (Oryzias melastigma) Chronically Exposed to the Antifouling and Chemopreventive Agent, 3,3′-Diindolylmethane (DIM). Lianguo Chen, Rui Ye, Weipeng Zhang, Chenyan Hu, Bingsheng Zhou, Drew R.Combined Transcriptomic and Proteomic Approach to Identify Toxicity Pathways in Early Life Stages of Japanese Medaka (Oryzias latipes) Exposed to 1,2,5,6-Tetrabromocyclooctane (TBCO). Jianxian Sun, Song Tang, Hui Peng, David M.V.Staphylococcus aureus sqr Encodes a Type II Sulfide:Quinone Oxidoreductase and Impacts Reactive Sulfur Speciation in Cells. Jiangchuan Shen, Hui Peng, Yixiang Zhang, Jonathan C.TiO2-Assisted Laser Desorption/Ionization Mass Spectrometry for Rapid Profiling of Candidate Metabolite Biomarkers from Antimicrobial-Resistant Bacteria. Rutan Zhang, Qin Qin, Baohong Liu, Liang Qiao.Environmental Science & Technology 2019, 53 Perfluorobutanesulfonate Exposure Skews Sex Ratio in Fish and Transgenerationally Impairs Reproduction. Proteomic Investigation of the Antibacterial Mechanism of trans-Cinnamaldehyde against Escherichia coli. Gao-Fei Du, Xing-Feng Yin, Dong-Hong Yang, Qing-Yu He, Xuesong Sun.
This article is cited by 54 publications. This report is the first in using label-free quantitative proteomics to study β-lactam antibiotic responses in S. These new data offer a more complete view of the proteome changes in bacteria in response to the antibiotic.
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More interestingly, the peptidoglycan biosynthesis pathway and the pantothenate and CoA biosynthesis pathway were found to be up-regulated in both oxacillin-treated MRSA and MSSA, and a series of energy metabolism pathways were up-regulated uniquely in oxacillin-treated MSSA. β-Lactamase and penicillin-binding protein 2a were observed up-regulated uniquely in oxacillin-treated MRSA, which is consistent with the known β-lactam resistance mechanisms of S. In comparison, 225 proteins (162 up-regulated, 63 down-regulated) were shown differentially expressed in oxacillin-treated MSSA. Upon treatment with oxacillin, 81 proteins (65 up-regulated, 16 down-regulated) were shown differentially expressed in MRSA ( p < 0.05). On average, 10 proteins were identified at a false discovery rate threshold of 0.01, for the untreated group of MRSA and MSSA. We developed a simple and easily repeated sample preparation procedure that is effective for extracting surface-associated proteins. aureus (MSSA) treated with subinhibitory doses of oxacillin, a model β-lactam antibiotic. Spectral counting-based label-free quantitative proteomics has been applied to study global responses in MRSA and methicillin-susceptible S. Although the resistance mechanisms of β-lactam antibiotics have been studied for decades, there are few attempts at systems-wide investigations into how the bacteria respond to antibiotic stress. Methicillin-resistant Staphylococcus aureus (MRSA) is the leading cause of fatal bacterial infections in hospitals and has become a global health threat.
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